Research Objectives

  1. Identifying and defining novel molecular and cellular pathways of bidirectional communication between neurons and glia in the developing and the adult brain

  2. Defining alterations of neuron-glia interactions in the diseased brain using epilepsy as a central paradigm

  3. Identifying how the innate and adaptive immune system affect epileptogenesis and disease progression via inflammatory responses

  4. Developing better research instrumentation, novel drug screening and evaluation assays and disease models to reveal the diversity of neuron-glia interactions in the healthy and the epileptic brain

The research, in which the young scientists of the EU-GliaPhD consortium will be trained, is centred on the role of neuron-glia interactions in brain function and pathology. Since epilepsy is a complex brain disorder exhibiting a variety of pathological events also seen in other CNS diseases, the research projects of the ESRs will focus on neuron-glia interactions in epilepsy as a single, but paradigmatic disease to guarantee a high degree of network cooperation and synergism. Addressing the role of glial cells in epilepsy research is a rather novel approach and has never been utilized in an international, collaborative training programme.